Functional Foods Business
Only One Material for People's Health
In order to manufacture safe and high quality products based on our cultivation technology cultivated for over 50 years, we manufacture our products in a hygienic environment and management methods in accordance with Good Manufacturing Practice (GMP) for dietary supplements, including a series of manufacturing processes and quality inspections, to ensure the safety of our products. We strive to ensure that our products are safe and effective. We are committed to providing reliable quality for your valuable products.
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Reliable and Safe Quality Management
Our fully integrated, GMP-certified manufacturing facility ensures strict quality control at every stage.
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Power of Naturally Derived Enzymes
Shiitake mycelium is rich in naturally derived enzymes that help maintain overall body balance and support healthy immune function.
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Diverse Applications of LEM
LEM, a bioactive extract from Shiitake mycelium, is gaining attention not only in dietary supplements but also in cosmetics, agriculture, and pet care products.
POINT_1
Reliable and Safe Quality Management
Our fully integrated, GMP-certified manufacturing facility ensures strict quality control at every stage. From the cultivation of Shiitake mycelium and Reishi mycelium to extraction, filling, and final packaging, all processes are carried out in-house using advanced, program-controlled equipment. This unified production system enables us to deliver consistently high-quality, safe, and trustworthy products.
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Power of Naturally Derived Enzymes
Shiitake mycelium is rich in naturally derived enzymes that help maintain overall body balance and support healthy immune function. With decades of specialized cultivation technology, we develop health supplements that maximize the natural “enzyme power” of Shiitake mycelium, delivering science-backed benefits for daily wellness.
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Diverse Applications of LEM
LEM, a bioactive extract from Shiitake mycelium, is gaining attention not only in dietary supplements but also in cosmetics, agriculture, and pet care products. Its wide range of benefits—including immune support, antioxidant activity, and plant growth enhancement—makes it a versatile natural ingredient used across multiple industries.
LEM - A Nutrient-Rich and Energy-Dense SHIITAKE Mycelium Cultivation Medium Extract
LEM is "SHIITAKE mycelium culture medium extract," a useful extract obtained from long-term cultivation of shiitake mycelium in a solid medium consisting of bagasse and non-fat rice bran.
LEM is a useful substance produced by the mycelium of SHIITAKE mushrooms (microorganisms), and thus belongs to the same category of fermented foods as natto, cheese, yogurt, miso, soy sauce, sake, lactic acid beverages, and so on.
How LEM is Produced.
LEM is produced by inoculating SHIITAKE mushroom fungi into a medium made from **bagasse** (the fibrous residue left after sugarcane extraction) and **rice sugar**. This extraction process utilizes the metabolites obtained during the growth of the shiitake fungi, along with components derived from the decomposition of the mycelium using its own enzymes. This unique manufacturing process ensures that LEM is rich in bioactive compounds with high physiological activity.
![Rich in nutrients and energy Extracts from shiitake mycelial culture medium [LEM].](../_src/87314194/image.webp?v=1763098677616)
Health Benefits of LEM: Extract from SHIITAKE Mycelial Culture Medium
**LEM** (SHIITAKE Mycelium Extract) is a valuable extract derived from the mycelium of the SHIITAKE mushroom (Lentinula edodes) that has been cultivated over an extended period. The mycelium of SHIITAKE mushrooms grows by decomposing organic materials such as sawdust and logs, eventually developing on the surface of these substrates. This process allows LEM to harness the power of nature as a health food, gaining significant attention.
Importance of the Fermentation Process
Fermentation is a process in which microorganisms and their enzymes generate substances that are beneficial to humans. Through this natural fermentation process, LEM is enriched with bioactive compounds that contribute to health promotion. As a result, LEM possesses characteristics that make it a gentle and effective health supplement.
Health Benefits of LEM
LEM is associated with a variety of health benefits, including:
**Immune Activation**: Enhances the body's immune response, protecting against infections and diseases.
**Antiviral Properties**: May help combat viral infections, supporting overall health.
**Antioxidant Effects**: Protects cells from oxidative stress, aiding in the prevention of chronic diseases and aging.
**Hepatocyte Protection**: Supports liver health and protects liver cells from damage.
Conclusion
LEM is a powerful extract derived from shiitake mycelial culture, maximizing the natural benefits of SHIITAKE mushrooms. With properties that enhance immune function, provide antiviral effects, offer antioxidant protection, and support liver health, LEM is an excellent health supplement for improving overall well-being. Consider incorporating LEM into your health regimen to take advantage of its numerous benefits. For a healthier lifestyle, be sure to try LEM!
The power of LEM and its evidence
LEM contains two types of active components: heteropolysaccharides and soluble lignin. Heteropolysaccharides arise primarily from cellulose and hemicellulose, which make up cell walls. The sugars that make up heteropolysaccharides are mainly pentasaccharides such as arabinose and xylose. In addition, water-soluble lignin is derived from water-insoluble lignin that is made soluble by breaking down the lignin that makes up the cell wall. LEM has a variety of effects, including immunomodulating, antiviral, antioxidant, and cancer cell growth inhibitory effects.
Safety of LEM
The shiitake mycelium used in the production of LEM is the same as that of edible shiitake mushrooms. Therefore, there are no safety issues. In addition, the safety of LEM has been confirmed through various safety tests, including toxicity and mutagenicity tests, conducted by an analytical institution.
| acute toxicity test LD50 mg/kg/day |
rat | male | 16,400 |
| female | 15,600 | ||
| mouse | male | 19,600 | |
| fermale | 17,700 | ||
| subacute toxicity test maximum no-action volumemg/kg/day |
rat | male | 3,840 |
| fermale | 7,980 | ||
| mouse | male | 6,740 | |
| fermale | 9,100 | ||
| genotoxicity test | gene mutation (Ames test) | negative | |
| DNA damege (Rec assay or umu test) | negative | ||
Example of LEM efficacy test (anti-influenza action)
▒ Inhibition of proliferation
After influenza viruses were infected cultured cells, a given concentration of LEM was added, and plaque area was compared by plaque assay. The results showed that LEM inhibited plaque area expansion in a concentration-dependent manner. This suggested that LEM inhibited the growth of influenza viruses.
The power of LEM and its evidence
LEM contains two types of active components: heteropolysaccharides and soluble lignin. Heteropolysaccharides arise primarily from cellulose and hemicellulose, which make up cell walls. The sugars that make up heteropolysaccharides are mainly pentasaccharides such as arabinose and xylose. In addition, water-soluble lignin is derived from water-insoluble lignin that is made soluble by breaking down the lignin that makes up the cell wall. LEM has a variety of effects, including immunomodulating, antiviral, antioxidant, and cancer cell growth inhibitory effects.
Safety of LEM
The shiitake mycelium used in the production of LEM is the same as that of edible shiitake mushrooms. Therefore, there are no safety issues. In addition, the safety of LEM has been confirmed through various safety tests, including toxicity and mutagenicity tests, conducted by an analytical institution.
| acute toxicity test LD50 mg/kg/day |
rat | male | 16,400 |
| female | 15,600 | ||
| mouse | male | 19,600 | |
| fermale | 17,700 | ||
| subacute toxicity test maximum no-action volumemg/kg/day |
rat | male | 3,840 |
| fermale | 7,980 | ||
| mouse | male | 6,740 | |
| fermale | 9,100 | ||
| genotoxicity test | gene mutation (Ames test) | negative | |
| DNA damege (Rec assay or umu test) | negative | ||
Example of LEM efficacy test (anti-influenza action)
▒ Inhibition of proliferation
After influenza viruses were infected cultured cells, a given concentration of LEM was added, and plaque area was compared by plaque assay. The results showed that LEM inhibited plaque area expansion in a concentration-dependent manner. This suggested that LEM inhibited the growth of influenza viruses.
Mice were infected with influenza virus through their nasal cavity and orally administered LEM for 7 days. As a result, the gross lesions with inflammation, hemorrhage and congestion in the lungs of mice orally administered LEM were much smaller than those of mice not administered LEM. This suggested that LEM suppressed lung inflammation.
PRODUCTS
GMP-Certified Headquarters Factory of Noda Shokukin Industry Co., Ltd.
To ensure safe, reliable, and high-quality products backed by more than 50 years of cultivation technology, our headquarters factory has obtained GMP certification for dietary supplements in accordance with the Ministry of Health, Labour and Welfare’s GMP guidelines (certified in 2018). With registered voluntary safety inspections and strict quality management, we manufacture all products under a thoroughly controlled, GMP-compliant system.
Production Facility
＞＞MAK
The extract from the cultured solid medium of Ganoderma lucidum mycelia.
Reishi Mycelium Extract “MAK”｜A Functional Health Ingredient Born from Natural Fermentation
MAK is a functional health ingredient developed in 1996, produced by cultivating and extracting traditional Reishi (Ganoderma lucidum) mycelium using modern fermentation technology. This naturally fermented Reishi mycelium extract is widely valued for use in dietary supplements and wellness products.
＞＞LEF
The extract from the rice bran by Lentinus edodes fermentation.
Shiitake-Fermented Rice Bran Extract (LEF)｜A High-Functionality Nutraceutical Powder Enhanced by Mycelial Enzymes
LEF is a powdered fermented ingredient produced by applying the powerful degrading enzymes of Shiitake mycelium to nutrient-rich rice bran, a widely recognized health material. This Shiitake-fermented rice bran extract contains α-glucans, β-glucans, and other high–molecular weight polysaccharides, offering enhanced functionality for use in health and wellness products.