Functional Foods Business
Only One Material for People's Health
In order to manufacture safe and high quality products based on our cultivation technology cultivated for over 50 years, we manufacture our products in a hygienic environment and management methods in accordance with Good Manufacturing Practice (GMP) for dietary supplements, including a series of manufacturing processes and quality inspections, to ensure the safety of our products. We strive to ensure that our products are safe and effective. We are committed to providing reliable quality for your valuable products.
POINT_1
Reliable and Safe Quality Management
Integrated Production System in a GMP-Certified Facility
POINT_2
The Power of Naturally Derived Enzymes
Supporting Health from Within with Enzymatic Strength
POINT_3
Diverse Applications of MAK
The Natural Power Supporting Health, Beauty, and the Environment
POINT_1
Reliable and Safe Quality Management
Integrated Production System in a GMP-Certified Facility
GMP-certified in-house factory, ensuring strict quality control from start to finish. From Reishi mycelium cultivation and extraction to filling and packaging, every process is carried out in-house using advanced, program-controlled equipment. This fully integrated system enables us to deliver consistently high-quality, safe, and trustworthy products for health and wellness applications.
POINT_2
The Power of Naturally Derived Enzymes
Supporting Health from Within with Enzymatic Strength
Reishi mycelium is rich in naturally derived enzymes that help support healthy immune function. Leveraging decades of proprietary cultivation technology, we develop health supplements that maximize the enzyme power of Reishi mycelium, delivering natural wellness benefits and supporting overall vitality.
POINT_3
Diverse Applications of MAK
The Natural Power Supporting Health, Beauty, and the Environment
Reishi mycelium is gaining attention not only in dietary supplements but also across a wide range of applications in health, beauty, and environmental solutions. It offers diverse bioactive benefits, including immune support, antioxidant activity, antitumor effects, neuroprotection, radiation defense, and support for metabolic syndrome. As a versatile functional ingredient, Reishi mycelium is valued for its scientifically backed contributions to wellness and holistic health.
The nutritional components of Ganoderma lucidum are completely different from those of Extracts from Ganoderma lucidum mycelium culture medium containing special ingredients [MAK].
Developed in 1996, MAK is a premium product extracted from Ganoderma lucidum, commonly known as Reishi or Mannentake, which has been highly valued in traditional Chinese medicine since ancient times. This innovative product is created through a specialized process that cultivates Reishi mushroom mycelium extracts.
MAK stands out due to its unique and beneficial compounds produced by the Ganoderma lucidum mycelium as it metabolizes and grows on nutrient-rich substrates such as bagasse and rice bran. These natural substances are believed to contribute to immune support and overall health enhancement.
By incorporating MAK into your "mycelium lifestyle," you can improve your health and vitality, making it an excellent choice for those seeking natural health solutions.
The nutritional components of Ganoderma lucidum are completely different from those of Extracts from Ganoderma lucidum mycelium culture medium containing special ingredients [MAK].
Developed in 1996, MAK is a premium product extracted from Ganoderma lucidum, commonly known as Reishi or Mannentake, which has been highly valued in traditional Chinese medicine since ancient times. This innovative product is created through a specialized process that cultivates Reishi mushroom mycelium
extracts.
MAK stands out due to its unique and beneficial compounds produced by the Ganoderma lucidum mycelium as it metabolizes and grows on nutrient-rich substrates such as bagasse and rice bran. These natural substances are believed to contribute to immune support and overall health enhancement.
By incorporating MAK into your "mycelium lifestyle," you can improve your health and vitality, making it an excellent choice for those seeking natural health solutions.
The Bioactive Components of MAK and Their Effects
MAK is rich in various bioactive compounds that contribute to health. Notably, it contains two primary components: heteropolysaccharides and water-soluble lignin. These compounds are produced by enzymes within the mycelium of **Astragalus membranaceus**, which also generates unique enzymes not found in shiitake mushroom mycelium.
Composition and Characteristics of Heteropolysaccharides
Heteropolysaccharides are primarily composed of pentasaccharides such as arabinose and xylose, as well as hexoses like glucose. These components play a significant role in various physiological functions within the body, particularly in enhancing immune function and providing antioxidant effects.
Diverse Health Benefits of MAK
MAK offers a wide range of health benefits, including:
1. **Antioxidant Effects**: Reduces oxidative stress in cells, contributing to the prevention of aging and diseases.
2. **Neuroprotective Effects**: Protects nerve cells and supports brain health.
3. **Blood Sugar Regulation**: Helps prevent rapid spikes in blood sugar levels, aiding in diabetes prevention.
4. **Blood Pressure Regulation**: Reduces the risk of hypertension and promotes cardiovascular health.
5. **Immune Modulation**: Adjusts immune system responses, enhancing resistance to infections.
6. **Antiviral Properties**: Strengthens the body’s defenses against viral infections.
7. **Mood Improvement**: Supports mental health and contributes to the reduction of stress and anxiety.
Conclusion
MAK, with its rich array of bioactive components, provides numerous health benefits. Its ability to enhance immune function and offer antioxidant protection is particularly important in today’s health-conscious society. By incorporating MAK into your daily routine, you can support health maintenance and disease prevention. Consider utilizing MAK as part of a health-focused lifestyle to reap its potential benefits.
Safety of MAK
The mycelium used in the production of MAK is the same as that of the edible mannentake mushroom. Therefore, there are no safety issues. The safety of MAK has been confirmed through various safety tests, including toxicity and mutagenicity tests, conducted by an analytical laboratory.
| Acute toxicity | rat | Threshold dose study No abnormality |
NLT 22,500mg/kg |
| mouse | 2,000mg/kg | ||
| Mutagenicity | Negative | ||
| Repeated-dose study (three months) |
rat (male) | NOAEL | 3,610mg/kg/day |
| rat (fermale) | NOAEL | 4,190mg/kg/day | |
Safety of MAK
The mycelium used in the production of MAK is the same as that of the edible mannentake mushroom. Therefore, there are no safety issues. The safety of MAK has been confirmed through various safety tests, including toxicity and mutagenicity tests, conducted by an analytical laboratory.
| Acute toxicity | rat | Threshold dose study No abnormality |
NLT 22,500mg/kg |
| mouse | 2,000mg/kg | ||
| Mutagenicity | Negative | ||
| Repeated-dose study (three months) |
rat (male) | NOAEL | 3,610mg/kg/day |
| rat (fermale) | NOAEL | 4,190mg/kg/day | |
▒ Brain cell protective effects
Type I diabetic mice were divided into three groups: one group received MAK (0.3 or 1 g/kg) dissolved in distilled water orally and the other group received distilled water only. Administration was done once a day for 7 days. Half of the brains were then treated with hypoxia and observed for brain cell protection. The results showed that the formation of cerebral infarcts was inhibited in the MAK-treated group. In particular, the inhibitory effect was particularly high in the 1 g/kg dose group.
▒ Brain cell protective effects
Type I diabetic mice were divided into three groups: one group received MAK (0.3 or 1 g/kg) dissolved in distilled water orally and the other group received distilled water only. Administration was done once a day for 7 days. Half of the brains were then treated with hypoxia and observed for brain cell protection. The results showed that the formation of cerebral infarcts was inhibited in the MAK-treated group. In particular, the inhibitory effect was particularly high in the 1 g/kg dose group.
PRODUCTS
GMP-Certified Headquarters Factory of Noda Shokukin Industry Co., Ltd.
To ensure safe, reliable, and high-quality products backed by more than 50 years of cultivation technology, our headquarters factory has obtained GMP certification for dietary supplements in accordance with the Ministry of Health, Labour and Welfare’s GMP guidelines (certified in 2018). With registered voluntary safety inspections and strict quality management, we manufacture all products under a thoroughly controlled, GMP-compliant system.
Production Facility
＞＞LEM
The extract from the cultured solid medium of Lentinus edodes mycelia.
Shiitake Mycelium | Kinshoku Life “LEM”
LEM is an extract obtained from solid-state substrates of Shiitake mycelium naturally fermented over approximately four months. This unique production process makes LEM a high-value, premium ingredient that stands apart from conventional mushroom extracts. Widely recognized for immune support, antioxidant benefits, and use as a functional food OEM ingredient, LEM is attracting attention in the health and wellness industry for its scientifically backed efficacy.
＞＞LEF
The extract from the rice bran by Lentinus edodes fermentation.
Shiitake-Fermented Rice Bran Extract (LEF)｜A Functional Powder Ingredient Enhanced by Enzymatic Power
LEF is a powdered fermented ingredient produced by applying the powerful degrading enzymes of Shiitake mycelium to nutrient-rich rice bran, a widely recognized health material. This Shiitake-fermented rice bran extract contains α-glucans, β-glucans, and other high–molecular weight polysaccharides, offering enhanced functionality for use in health and wellness products.