Research and Development
Science of the mysteries of life and pursuit of natural mechanisms.
Research and Development of LEM & MAK
Recently, fermented foods have been attracting attention as health foods. Fermented foods [LEM][MAK] developed by Noda Shokubutsu Kogyo are packed with unknown power that has yet to be elucidated, with more than 90 patents, 100 papers published, and presentations at domestic academic conferences. We aim to establish a variety of backup systems, including product development by researchers in our own laboratory, sales and support by our sales staff, and the pursuit of evidence through our network of medical institutions and public organizations.
At Noda Shokukin, we place great importance on scientific evidence for our ingredients. We have obtained a number of various patents based on this data and strive to ensure the reliability and certainty of our products through academic papers.
Collaborative Research
We conduct joint research with universities and medical institutions and publish the results in academic papers. We are working to expand the possibilities of functional foods in collaboration with the Japanese Pharmaceutical Society, Complementary and Alternative Medicine (CAM), and the field of integrative medicine.
[Basic study]
■ UNIVERSITY OF TOYAMA
■ JOSAI UNIVERSITY
■ UNIVERSITY OF TSUKUBA
■ KINDAI UNIVERSITY
■ UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTALHEALTH,JAPAN
■ Fukuoka University
■ Fukuyama University
[Clinical trials]
■ KEIJU MEDICAL CENTER
■ ORIENTM MITAKA-CLINIC
■ YUKAWA ICHO HOSPITAL
Evidence: Examples of MAK Academic Reports
There are many academic reports regarding MAK.
<Examples>
- MAK suppresses the proliferation of the hepatitis C virus. (YUKAWA ICHO HOSPITAL / Dr.TAKASHIMA)
- MAK suppresses metabolic syndrome.
- MAK shows protective effects against brain damage caused by transient cerebral ischemia.
■ Clinical Trial of Hepatitis C Treatment with MAK (Mannentake Mushroom Mycelium Extract)
<Product Summary>
MAK is commercially available as a health food and has a high safety profile.
<Trial Summary>
In six cases of chronic hepatitis C and cirrhosis [ages 57 to 77 (average age 67), 2 males and 4 females], MAK was administered at a dose of 6g per day for 12 months. Liver function tests, core antibody levels, and HCV-RNA quantities were measured monthly.
<Test Results>
- The administration of MAK resulted in a decrease in AST and ALT levels in half of the cases.
- It is believed that MAK can improve the degree of hepatocellular damage.
- A significant reduction in viral load was observed in one case, with a decrease of 17%, suggesting the possibility of viral suppression.
- No adverse effects or worsening of symptoms were observed during the treatment.
<Conclusion>
The therapeutic effect of MAK on hepatitis C is considered to be gradual but highly beneficial.
List of MAK Academic Reports examples
- Kohayakawa S. et al. (2018) Anti-allergic effects of a water-soluble lignin rich fraction (JLS-18) prepared from the extract of culture medium of Lentinus edodes mycelia (LEM). New food industry 60. 42-48. (In Japanese)
- 岩田直洋 (2019) 虚血性脳障害に対する霊芝菌糸体培養培地抽出物の脳保護効果. アグリバイオ 3, 1072–1074
- 神内伸也ら (2018) 霊芝菌糸体培養培地抽出物の血糖上昇抑制作用と抗酸化作用. New food industry 60, 1–12
- 小早川幸子ら (2018) 霊芝菌糸体培養培地抽出物(MAK)の肥満細胞の脱顆粒抑制による抗アレルギー効果. New food industry 60, 8–14
- 岩田直洋 (2018) 一過性脳虚血に対する霊芝菌糸体培養培地抽出物の脳保護効果. アグリバイオ 2, 1095–1097
- 助川寧ら (2017) 担癌マウスにおけるCyclophosphamideと椎茸菌糸体培養培地抽出物（LEM）・霊芝菌糸体培養培地抽出物（MAK）の併用による延命効果. 癌と化学療法 44, 896–899
- 岩田直洋ら (2017) 霊芝菌糸体培養培地抽出物(MAK)による虚血性脳障害の軽減メカニズム. New food industry 59, 15–30
- Nagai K. et al. (2017) Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages. Cellular Immunology 320, 20–28
- 神内伸也ら (2016) 霊芝菌糸体培養培地抽出物の2型糖尿病マウス肝臓の脂質代謝に与える影響. New food industry 58, 5–12
- 神内伸也ら (2015) 霊芝菌糸体培養培地抽出物のラット骨格筋培養細胞におけるGLUT4膜移行促進作用. 日本補完代替医療学会誌 12, 19–27
- 深谷睦ら (2015) 高血圧自然発症ラットにおける霊芝菌糸体培養培地抽出物(MAK)の血圧上昇抑制作用. New food industry 57, 1–11
- Xuan M. et al. (2015) Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain. Evid Based Complement Alternat Med 2015, 865986
- Nagai K. et al. (2015) The Potential Role of Polysaccharides Derived from Ganoderma Lucidum Fungus Mycelia (designated as MAK) on Ameliorating Indomethacin-Induced Small Intestinal Injuries Through GM-CSF. Gastroenterology 148, S-919
- 神内伸也ら (2014) 2型糖尿病マウスの肝臓における霊芝菌糸体培養培地抽出物(WER)の糖質代謝に与える影響. 日本補完代替医療学会誌 11, 57–66
- 岩田直洋 (2014) 虚血性脳障害メカニズムと抗酸化作用を有する食品の脳保護効果に関する基礎的研究.城西大学学位論文
- 渡辺敦光 (2013) 霊芝菌糸体培養基熱水抽出物(紅芝泉、MAK)の効用. 温古知新
-
- 玄美燕 (2013) 霊芝菌糸体培養培地抽出物中の抗酸化活性成分の探索と脳保護効果に関する研究. 城西大学学位論文
- Watanabe H. et al. (2013) Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats. Med Mol Morphol 46, 97–103
- 18 Matsuzaki H. et al. (2013) Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complementary and Alternative Medicine 13, 370
- Iwata N. et al. (2012) Diabetes-Mediated Exacerbation of Neuronal Damage and Inflammation After Cerebral Ischemia in Rat: Protective Effects of Water-Soluble Extract from Culture Medium of Ganoderma lucidum Mycelia, Advances in the Preclinical Study of Ischemic Stroke
- 川原由紀子ら (2011) 2型糖尿病マウスにおける霊芝菌糸体培養培地抽出物の糖負荷後の血糖上昇抑制効果と食後過血糖改善薬との併用効果. 日本補完代替医療学会誌 8, 1–9
- Hanaoka R. et al. (2011) The Water-Soluble Extract from Cultured Medium of Ganoderma lucidum (Reishi) Mycelia (Designated as MAK) Ameliorates Murine Colitis Induced by Trinitrobenzene Sulphonic Acid. Scandinavian Journal of Immunology 74, 454–462
- 神内伸也ら (2010) 2型糖尿病マウスにおける霊芝菌糸体培養培地抽出物の血糖上昇抑制効果. 日本補完代替医療学会誌 7, 35–42
- 樫本尚樹ら (2010) 霊芝菌糸体培養基熱水抽出物(MAK)による大腸前癌病変ならびに小腸腺窩障害の抑制. 日本未病システム学会雑誌 16, 417–419
- Oka S. et al. (2010) A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J. Med. Sci. 59, 1–6
- Kashimoto N. et al. (2010) A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs. Oncology Letters 1, 63–68
- 岩田直洋ら (2008) 糖尿病態ラットの一過性脳虚血誘発脳障害に対する霊芝菌糸体培養培地抽出物の保護効果. 日本栄養・食糧学会誌 61, 119–127
- 岡崎真理ら (2008) 霊芝菌糸体培養培地抽出物の抗酸化活性とストレプトゾトシン糖尿病マウスにおける改善効果. 日本補完代替医療学会誌5, 209–218
-
- 岡崎真理ら (2008) マウス低酸素脳虚血障害に対する霊芝菌糸体培養培地抽出物の保護効果. 日本補完代替医療学会誌 5, 153–162
- 臼井達洋ら (2007) 霊芝菌糸体培養培地抽出物の糖負荷後の血糖上昇抑制効果と食後過血糖改善薬との併用効果. 日本栄養・食糧学会誌 60, 249–255
- 樫本尚樹ら (2006) N-nitrosobis (2-hydroxypropyl) amine (BHP)誘発肺癌モデルに対する霊芝菌糸体培養基熱水抽出物(MAK)の予防効果. 日本未病システム学会雑誌 12, 139–141
- Kashimoto N. et al. (2006) Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats. Oncology Reports 16, 1181–1187
- 明神有紀ら (2005) 霊芝菌糸体培養基熱水抽出物(MAK)による5FU毒性の軽減作用. 日本未病システム学会雑誌 11, 157–160
- 樫本尚樹ら (2005) 霊芝菌糸体培養基熱水抽出物(MAK)のデキストラン硫酸ナトリウム誘発潰瘍性大腸炎モデルに対する効果. 日本未病システム学会雑誌 11, 153–156
- Kubo N. et al. (2005) Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia andAgaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. International Journal of Molecular Medicine 15, 401–406
- 久保ナナミら (2004) 放射線防御作用の検討. 日本未病システム学会雑誌 10, 69–74
- 樫本尚樹ら (2003) 霊芝菌糸体培養基熱水抽出物(MAK)の免疫アジュバント作用. 日本未病システム学会雑誌 9, 293–296
-
- Lu H. et al. (2003) A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. Oncology Reports 10, 375–379
- 陸惠梅 (2002) 霊芝菌糸体培養基熱水抽出物によるN, N′-dimethylhydrazine誘発マウス大腸腫瘍の抑制効果. 広島大学学位論文
- 陸恵梅ら (2002) Azoxymethane誘発ラット大腸腫瘍の霊芝菌糸体培養基熱水抽出物(MAK)による抑制効果. 日本未病システム学会雑誌 8, 235–237
- Lu H. et al. (2002) Prevention of development of N,N’-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice. International Journal of Molecular Medicine 9, 113–117
- 陸恵梅ら (2001) 霊芝菌糸体培養基熱水抽出物 (MAK) によるN, N’-dimethylhydrazine塩酸塩 (DMH) 誘発マウス大腸腫瘍の抑制効果. 日本未病システム学会雑誌 7, 12–13
- Lu H. et al. (2001) Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncology Reports 8, 1341–1345
- 陸恵梅ら (2000) 霊芝菌糸体培養基熱水抽出物（MAK）のAzoxymethane（AOM）誘発Aberrant crypt foci（ACF）の抑制効果. 日本未病システム学会雑誌 6, 72–74
- 中川育也ら (1999) マンネンタケ（霊芝）菌糸体培養基より得られるヘテロ多糖・蛋白質画分（MTP2）によるマウス脾細胞の傷害活性の増強. Biotherapy 13, 513–515
- 中川育也ら (1998) マンネンタケ（霊芝）菌糸体培養基より得られる多糖蛋白質画分（MTP2）の免疫賦活性：サイトカインとNOの産生誘導. Biotherapy 12, 751
List of MAK Academic Reports examples
- Kohayakawa S. et al. (2018) Anti-allergic effects of a water-soluble lignin rich fraction (JLS-18) prepared from the extract of culture medium of Lentinus edodes mycelia (LEM). New food industry 60. 42-48. (In Japanese)
- 岩田直洋 (2019) 虚血性脳障害に対する霊芝菌糸体培養培地抽出物の脳保護効果. アグリバイオ 3, 1072–1074
- 神内伸也ら (2018) 霊芝菌糸体培養培地抽出物の血糖上昇抑制作用と抗酸化作用. New food industry 60, 1–12
- 小早川幸子ら (2018) 霊芝菌糸体培養培地抽出物(MAK)の肥満細胞の脱顆粒抑制による抗アレルギー効果. New food industry 60, 8–14
- 岩田直洋 (2018) 一過性脳虚血に対する霊芝菌糸体培養培地抽出物の脳保護効果. アグリバイオ 2, 1095–1097
- 助川寧ら (2017) 担癌マウスにおけるCyclophosphamideと椎茸菌糸体培養培地抽出物（LEM）・霊芝菌糸体培養培地抽出物（MAK）の併用による延命効果. 癌と化学療法 44, 896–899
- 岩田直洋ら (2017) 霊芝菌糸体培養培地抽出物(MAK)による虚血性脳障害の軽減メカニズム. New food industry 59, 15–30
- Nagai K. et al. (2017) Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages. Cellular Immunology 320, 20–28
- 神内伸也ら (2016) 霊芝菌糸体培養培地抽出物の2型糖尿病マウス肝臓の脂質代謝に与える影響. New food industry 58, 5–12
- 神内伸也ら (2015) 霊芝菌糸体培養培地抽出物のラット骨格筋培養細胞におけるGLUT4膜移行促進作用. 日本補完代替医療学会誌 12, 19–27
- 深谷睦ら (2015) 高血圧自然発症ラットにおける霊芝菌糸体培養培地抽出物(MAK)の血圧上昇抑制作用. New food industry 57, 1–11
- Xuan M. et al. (2015) Chronic Treatment with a Water-Soluble Extract from the Culture Medium of Ganoderma lucidum Mycelia Prevents Apoptosis and Necroptosis in Hypoxia/Ischemia-Induced Injury of Type 2 Diabetic Mouse Brain. Evid Based Complement Alternat Med 2015, 865986
- Nagai K. et al. (2015) The Potential Role of Polysaccharides Derived from Ganoderma Lucidum Fungus Mycelia (designated as MAK) on Ameliorating Indomethacin-Induced Small Intestinal Injuries Through GM-CSF. Gastroenterology 148, S-919
- 神内伸也ら (2014) 2型糖尿病マウスの肝臓における霊芝菌糸体培養培地抽出物(WER)の糖質代謝に与える影響. 日本補完代替医療学会誌 11, 57–66
- 岩田直洋 (2014) 虚血性脳障害メカニズムと抗酸化作用を有する食品の脳保護効果に関する基礎的研究.城西大学学位論文
- 渡辺敦光 (2013) 霊芝菌糸体培養基熱水抽出物(紅芝泉、MAK)の効用. 温古知新
-
- 玄美燕 (2013) 霊芝菌糸体培養培地抽出物中の抗酸化活性成分の探索と脳保護効果に関する研究. 城西大学学位論文
- Watanabe H. et al. (2013) Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats. Med Mol Morphol 46, 97–103
- 18 Matsuzaki H. et al. (2013) Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complementary and Alternative Medicine 13, 370
- Iwata N. et al. (2012) Diabetes-Mediated Exacerbation of Neuronal Damage and Inflammation After Cerebral Ischemia in Rat: Protective Effects of Water-Soluble Extract from Culture Medium of Ganoderma lucidum Mycelia, Advances in the Preclinical Study of Ischemic Stroke
- 川原由紀子ら (2011) 2型糖尿病マウスにおける霊芝菌糸体培養培地抽出物の糖負荷後の血糖上昇抑制効果と食後過血糖改善薬との併用効果. 日本補完代替医療学会誌 8, 1–9
- Hanaoka R. et al. (2011) The Water-Soluble Extract from Cultured Medium of Ganoderma lucidum (Reishi) Mycelia (Designated as MAK) Ameliorates Murine Colitis Induced by Trinitrobenzene Sulphonic Acid. Scandinavian Journal of Immunology 74, 454–462
- 神内伸也ら (2010) 2型糖尿病マウスにおける霊芝菌糸体培養培地抽出物の血糖上昇抑制効果. 日本補完代替医療学会誌 7, 35–42
- 樫本尚樹ら (2010) 霊芝菌糸体培養基熱水抽出物(MAK)による大腸前癌病変ならびに小腸腺窩障害の抑制. 日本未病システム学会雑誌 16, 417–419
- Oka S. et al. (2010) A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J. Med. Sci. 59, 1–6
- Kashimoto N. et al. (2010) A water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia attenuates the small intestinal injury induced by anti-cancer drugs. Oncology Letters 1, 63–68
- 岩田直洋ら (2008) 糖尿病態ラットの一過性脳虚血誘発脳障害に対する霊芝菌糸体培養培地抽出物の保護効果. 日本栄養・食糧学会誌 61, 119–127
- 岡崎真理ら (2008) 霊芝菌糸体培養培地抽出物の抗酸化活性とストレプトゾトシン糖尿病マウスにおける改善効果. 日本補完代替医療学会誌5, 209–218
- 岡崎真理ら (2008) マウス低酸素脳虚血障害に対する霊芝菌糸体培養培地抽出物の保護効果. 日本補完代替医療学会誌 5, 153–162
- 臼井達洋ら (2007) 霊芝菌糸体培養培地抽出物の糖負荷後の血糖上昇抑制効果と食後過血糖改善薬との併用効果. 日本栄養・食糧学会誌 60, 249–255
- 樫本尚樹ら (2006) N-nitrosobis (2-hydroxypropyl) amine (BHP)誘発肺癌モデルに対する霊芝菌糸体培養基熱水抽出物(MAK)の予防効果. 日本未病システム学会雑誌 12, 139–141
- Kashimoto N. et al. (2006) Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats. Oncology Reports 16, 1181–1187
- 明神有紀ら (2005) 霊芝菌糸体培養基熱水抽出物(MAK)による5FU毒性の軽減作用. 日本未病システム学会雑誌 11, 157–160
- 樫本尚樹ら (2005) 霊芝菌糸体培養基熱水抽出物(MAK)のデキストラン硫酸ナトリウム誘発潰瘍性大腸炎モデルに対する効果. 日本未病システム学会雑誌 11, 153–156
- Kubo N. et al. (2005) Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia andAgaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death. International Journal of Molecular Medicine 15, 401–406
- 久保ナナミら (2004) 放射線防御作用の検討. 日本未病システム学会雑誌 10, 69–74
- 樫本尚樹ら (2003) 霊芝菌糸体培養基熱水抽出物(MAK)の免疫アジュバント作用. 日本未病システム学会雑誌 9, 293–296
-
- Lu H. et al. (2003) A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. Oncology Reports 10, 375–379
- 陸惠梅 (2002) 霊芝菌糸体培養基熱水抽出物によるN, N′-dimethylhydrazine誘発マウス大腸腫瘍の抑制効果. 広島大学学位論文
- 陸恵梅ら (2002) Azoxymethane誘発ラット大腸腫瘍の霊芝菌糸体培養基熱水抽出物(MAK)による抑制効果. 日本未病システム学会雑誌 8, 235–237
- Lu H. et al. (2002) Prevention of development of N,N’-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice. International Journal of Molecular Medicine 9, 113–117
- 陸恵梅ら (2001) 霊芝菌糸体培養基熱水抽出物 (MAK) によるN, N’-dimethylhydrazine塩酸塩 (DMH) 誘発マウス大腸腫瘍の抑制効果. 日本未病システム学会雑誌 7, 12–13
- Lu H. et al. (2001) Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncology Reports 8, 1341–1345
- 陸恵梅ら (2000) 霊芝菌糸体培養基熱水抽出物（MAK）のAzoxymethane（AOM）誘発Aberrant crypt foci（ACF）の抑制効果. 日本未病システム学会雑誌 6, 72–74
- 中川育也ら (1999) マンネンタケ（霊芝）菌糸体培養基より得られるヘテロ多糖・蛋白質画分（MTP2）によるマウス脾細胞の傷害活性の増強. Biotherapy 13, 513–515
- 中川育也ら (1998) マンネンタケ（霊芝）菌糸体培養基より得られる多糖蛋白質画分（MTP2）の免疫賦活性：サイトカインとNOの産生誘導. Biotherapy 12, 751
① Key Points
•This study aims to clarify the effects of MAK on H/I-induced infarction and neurological deficits.
•Effects of MAK:
•The enlargement of cerebral infarction in KKAy was alleviated in the MAK groups.
•In the rotarod test, H/I and subsequent reoxygenation significantly impaired motor coordination and balance in the control group, whereas the sham operation itself did not cause any deficits.
•Pretreatment with MAK significantly and dose-dependently suppressed deficits in locomotive function.
・Compared to the control group, the MAK (1 g/kg) group showed a better neurological score.
We can also provide you with samples of each raw material.
We can also provide you with samples of each raw material.