Functional Foods Business
Only One Material for People's Health
In order to manufacture safe and high quality products based on our cultivation technology cultivated for over 50 years, we manufacture our products in a hygienic environment and management methods in accordance with Good Manufacturing Practice (GMP) for dietary supplements, including a series of manufacturing processes and quality inspections, to ensure the safety of our products. We strive to ensure that our products are safe and effective. We are committed to providing reliable quality for your valuable products.
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Reliable and Safe Quality Management
Integrated Production System in a GMP-Certified Facility
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The Power of Naturally Derived Enzymes
Supporting Health from Within with Enzymatic Strength
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Diverse Applications of LEF
Harnessing the Natural Power Supporting Health, Beauty, and Wellness
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Reliable and Safe Quality Management
Integrated Production System in a GMP-Certified Facility
All production is centralized at our GMP-certified in-house factory, ensuring strict quality control at every stage. Leveraging the enzymatic power of Shiitake mycelium, we have developed a novel fermented rice bran extract, produced entirely in-house. This fully integrated production system enables us to consistently deliver high-quality, safe, and innovative health products for dietary supplements and wellness applications.
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The Power of Naturally Derived Enzymes
Supporting Health from Within with Enzymatic Strength
Our Shiitake-fermented rice bran extract contains polysaccharides such as α-glucans that help support healthy immune function. By maximizing the enzymatic power inherent in both rice bran and Shiitake mycelium, we develop functional health supplements that promote wellness from the inside out, offering natural and scientifically backed benefits.
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Diverse Applications of LEF
Harnessing the Natural Power Supporting Health, Beauty, and Wellness
Shiitake-fermented rice bran extract (LEF) is gaining attention not only in dietary supplements but also across a wide range of applications in health, beauty, and wellness products. LEF delivers multiple bioactive benefits, including immune support, anti-anxiety effects, and synergistic interactions with protein beverages, making it a versatile ingredient for functional foods and health-focused formulations.
Fermented Rice Bran Extract with Shiitake Mushrooms – LEF
LEF is a unique fermented functional ingredient derived from shiitake mushroom (Lentinula edodes) cultures applied to pre-treated rice bran. Developed in 2003 at our GMP-certified facility, this extract utilizes the powerful enzymes produced by shiitake mushrooms to transform the polysaccharides found in rice bran—primarily cellulose and hemicellulose—into bioactive, functional alpha-glucans and β-glucans.
These transformed polysaccharides are typically indigestible dietary fibers but become highly functional through fermentation. LEF offers potential applications in immune support, gut health, and natural supplement formulations. It is available in powder form, ideal for use in supplements, health drinks, and functional foods.
LEF is Strengths and Evidence
The characteristics of "LEF" include polysaccharides such as "hemicellulose," "β-glucan," and "α-glucan" as its main components, along with proteins and minerals.
Safety of LEF
LEF is made from "shiitake" and "rice bran," both of which have been used as food for a long time, ensuring its safety. Additionally, various safety tests, including toxicity tests and mutagenicity tests, have been conducted by analytical institutions, confirming its safety.
LEF Manufacturing Process
The enzymes from the mycelium of shiitake mushrooms are reacted with rice bran and extracted through a special treatment.
**Reaction** React the pre-treated rice bran with enzymes from shiitake mushroom.
**Decomposition** After the reaction is complete, ferment it.
**Extraction** Extract using ultracentrifugation.
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Antianxiety Effects of LEF
Glass Ball Concealment Test
Mice instinctively feel fear towards glowing objects, and this fear is considered a model for human obsessive-compulsive disorder. We confirmed whether oral intake of LEF alleviates anxiety resembling obsessive-compulsive disorder. After preliminary breeding, the mice were evenly divided into three groups and fed different diets for 10 days.
As a result, both LEF and LLM significantly (p<0.05) increased the number of glass balls that were not concealed, thereby reducing anxiety.
Antitumor Effects of LEF
Antitumor Test – Mouse Lifespan Effect
We conducted tests to determine whether LEF has antitumor effects (lifespan extension). Mice (C57BL10 ♂) were divided into two groups: a control group and an LEF group (10 mice each). The control group was given regular feed, while the LEF group was given feed mixed with 0.9% LEF, allowing free intake. After one week, tumors (S1048B10) were implanted, and the mice were observed until they died from cancer.
PRODUCTS
Harmonizing with Nature While Leading Innovation – Our Product Philosophy
At Noda Shokukin Industry Co., Ltd., our philosophy is to develop natural, high-quality health supplements that harmonize with nature while leveraging cutting-edge production technologies. Our second factory specializes in producing Shiitake-fermented rice bran extract (LEF) through advanced liquid-state mycelial fermentation technology. The facility is also fully equipped for powdered product manufacturing, ensuring consistent quality, safety, and functionality. By combining nature-derived functional ingredients with state-of-the-art processes, we deliver premium health solutions trusted in dietary supplements and wellness applications worldwide.
Production Facility
＞＞LEM
The extract from the cultured solid medium of Lentinus edodes mycelia.
Shiitake Mycelium | Kinshoku Life “LEM”
LEM is an extract derived from solid-state substrates of Shiitake mycelium naturally fermented over approximately four months. This unique production process makes LEM a high-value, premium ingredient that stands apart from conventional mushroom extracts. LEM is widely recognized for its immune support, antioxidant properties, and as a versatile OEM ingredient for functional foods, making it a highly sought-after component in health and wellness product development.
＞＞MAK
The extract from the cultured solid medium of Ganoderma lucidum mycelia.
Reishi Mycelium Extract “MAK”｜Premium Functional Health Ingredient from Natural Fermentation
MAK is a premium functional health ingredient developed in 1996 by cultivating and extracting traditional Reishi (Ganoderma lucidum) mycelium using advanced mycelial fermentation technology. This naturally fermented Reishi extract is highly valued as a bioactive mushroom ingredient for dietary supplements, wellness products, and other functional health applications, providing scientifically supported benefits for overall health and immune support.